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KMID : 0882420050690000939
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Korean Journal of Medicine
2005 Volume.69 No. 0 p.939 ~ p.942
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Postpartum thrombotic thrombocytopenic purpura
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Sun Gill-Hong
Park Chi-Young
Chung Choon-Hae
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Abstract
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Thrombotic thrombocytopenic purpura (TTP) is a life threatening disease, characterized by Moschcowitz’s pentad: thrombocytopenia, microangiopathic hemolytic anemia, fluctuating neurological signs, renal failure, and fever. Plasma exchange is the essential therapy for TTP, dramatically improving survival from less than 10% to approximately 80%. However, the decision to initiate plasma exchange is difficult in women during pregnancy or immediately postpartum, because preeclampsia, eclampsia, and HELLP (Hemolysis, Elevated Liver function tests, Low Platelets) syndrome can have all of the clinical features of TTP. The decision to intervene with plasma exchange treatment is based upon the severity of thrombocytopenia, microangiopathic hemolytic anemia, neurologic signs, and renal failure, the course of these abnormalities following delivery, and evaluation of ADAMTS-13 activity.
We experienced a case of TTP coexisted with preeclampsia, so we report it with a brief review of literature.(Korean J Med 69:S939-S942, 2005)
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KEYWORD
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Thrombotic thrombocytopenic purpura, Plasma exchange, Preeclampsia
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